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Description
토피메이트정(Diet)1) , 1. 1) : 6 2 2) : 1 2 . 2 1 2. 2) , [() 5385, 2014. 10. 06 . . , . . . 1. 1) : , . 2 1 3 ( "5. " ). , . . (17 ) : 1 25mg . , 1 2 1 25 50 1 2 , , . . 1 100200mg. 1 500mg. 1 1,000 . (6 16) 1 0. 5 1mg kg . 1 2 1 0. 5 1 1 2 , , , . . 1 3 6mg kg. 1 500 . 2) (17 ) 1 200mg 1 200 400mg 2 . 1 800mg . 1 25 50mg , . 1 2 25 50mg 1 2 . . . (2 16)1 5 9mg kg, 1 2 . 1 25mg( , 1 1 3mg kg ) , 1 2 1 1 3mg kg 1 2 . . 1 30mg kg , . 2. : 1 25mg . 1 25mg . , . 1 100mg 1
1) 효능,효과
1. 간질
1) 단독요법 : 6세 이상의 소아 및 성인에서의 2차성 전신발작을 동반하거나 동반하지 않은 부분발작 치료
2) 부가요법 : 기존 1차 항전간제 투여로 적절하게 조절이 되지 않는 2세 이상의 소아 및 성인에게서 다음 질환에 사용된다.
- 2차성 전신발작을 동반하거나 동반하지 않은 부분발작
- 레녹스-가스토 증후군과 관련된 발작
- 1차성 강직성/간대성 전신발작
2. 편두통의 예방
2) 용법,용량
[허가사항변경(통일조정) 의약품심사조정과-5385, 2014.10.06
이 약은 낮은 용량에서 시작하여 유효용량까지 증량하는 것이 바람직하다.
이 약의 투여를 최적화하기 위해 혈중농도를 모니터할 필요는 없다.이 약의 권장용량은 신장질환이 없는 경우, 노인을 포함한 모든 성인 및 소아에게 그대로 적용한다.
식사와 관계없이 투여할 수 있다.
정제는 부수지 말고 그대로 복용해야 한다.
1. 간질
1) 단독요법 : 단독요법으로 토피라메이트를 투여하기 위해 병용중인 다른 항전간약물을 중단할 경우, 발작조절에 미칠 수 있는 영향을 고려해야 한다. 안전성 문제로 다른 항전간약물을 즉시 중단해야 하는 경우를 제외하고는 2주 간격으로 다른 항전간약물을 1/3정도로 단계적으로 감량 중단하도록 한다(사용상 주의사항 "5. 일반적 주의"항 참조).
약물대사 효소 유도 약물을 중단시, 토피라메이트 농도가 상승할 수 있다. 만약 임상적으로 토피라메이트의 농도 상승이 나타날 경우 이 약의 용량을 감량할 필요가 있다.
성인 (17세 이상) :
처음 1주일 동안 저녁에 25mg씩 투여를 시작한다. 이후, 1-2주 간격으로 1일 25 또는 50㎎씩 증량하여 1일 2회로 나누어 투여하도록 하며, 만약 환자가 이러한 증량 경과를 견디기 어려워지면, 증량간격을 길게하도록 한다. 용량이나 증량속도는 임상적 반응에 따라 결정한다. 성인에 대한 단독요법으로서의 권장용량은 1일 100～200mg이다. 최대 권장용량은 1일 500mg이다. 재발된 간질 환자 중 일부는 토피라메이트 단독요법시 1일 1,000㎎까지 내약성이 있었다.
소아(6-16세)
처음 1주일 동안은 저녁에 0.5-1mg/kg으로 투여를 시작한다. 이후 1-2주 간격으로 1일 0.5-1㎎/㎏씩 증량하여 1일 2회 투여하도록 하며, 만약 환자가 증량을 견디기 어려워하면, 증량단위를 줄이거나, 증량간격을 늘리도록 한다. 용량이나 증량정도는 임상반응에 따라 결정한다.
소아에 대한 단독요법으로서의 권장용량은 1일 3-6mg/kg이다. 부분발작으로 진단된 소아의 경우 1일 500㎎까지 투여한 경험이 있다.
2) 부가요법
성인(17세 이상)
최소유효량은 1일 200mg이며 통상 1일 200-400mg을 2회로 나누어 투여한다. 환자에 따라 최대 권장용량인 1일 800mg까지 투여할 수 있다. 처음 1주일 동안은 저녁에 25-50mg씩 투여하는 것으로 치료를 시작하며, 더 낮은 용량에서 시작하는 것도 가능하다. 이후에는 1-2주 간격으로 용량은 25-50mg씩 증량하여 1일 2회로 나누어 투여한다. 만약 환자가 증가용량을 견디기 어렵다면 더 적은 용량을 증가시키거나 증량 간격을 연장시킬 수 있다. 투여량은 임상효과에 따라 결정하여야 한다.
소아(2세-16세)
1일 권장용량은 약 5-9mg/kg이며, 1일 2회로 나누어 투여한다. 처음 1주일 동안은 25mg(또는 그 이하, 1일 1-3mg/kg을 기준으로 함)을 저녁에 투여하고, 이후에는 적절한 임상효과가 나타날 때까지 1-2주 간격으로 1일 1-3mg/kg씩 증량하여 1일 2회로 나누어 투여한다. 용량 적정은 임상효과에 따라 결정하여야 한다. 1일 30mg/kg까지 투여된 경우도 있으며, 이 경우 일반적으로 내약성이 좋았다.
2. 편두통의 예방
성인 : 처음 1주일 동안은 저녁에 이 약 25mg으로 투여를 시작한다. 이후 1주 간격으로 25mg/일 씩 증량한다. 만약 환자가 이러한 증량을 견디기 어려워하면, 증량간격을 길게 하도록 한다. 1일 권장용량은 100mg으로 1일 2회로 분할하여 투여하도록 한다. 일부 환자에서는 1일 50mg 용량에서도 효과를 나타낼수 있다. 1일 200mg까지 투여할수 있으며, 용량 및 증량 속도는 임상반응에 따라 결정 하도록 한다.
3. 신장애 환자
- 중등도 및 중증 (CLcr < 70 mL/min/1.73 m2)의 신장애 환자는 시작용량 및 유지용량의 약 1/2로 감량하는 것이 권장된다.
- 혈액투석환자: 이 약은 혈액투석으로 혈장에서 제거되기 때문에 혈액투석환자는 투석 당일에 이 약 투여용량을 약 1/2 증량한다. 투석에 걸리는 시간, 투석장치의 청소율 및 투석환자의 신청소율 등을 고려하여 투여량을 증량하고, 혈액투석의 시작과 종료 시에 분할 투여한다.
4. 간장애 환자
간장애 환자들은 이 약의 클리어런스가 감소될 수 있으므로 주의하여 투여하여야 한다.
3) 포장단위
200정
4) 성분,함량
토피라메이트 토피라메이트 25mg
5) 사용기간
제조일로부터 36 개월
6) 보관방법
기밀용기, 실온(1~30°C)보관
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4.1 ★★★★★
Based on 5 reviews
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Product Reviews
★★★★★ 5
A must-have high-tech gear for cooking
Size: 2 Probes, Size: 2 Probes
I've been looking at wireless thermometers for while but was unsure about which brand to choose. Then I saw someone on YouTube use the Sync to cook a Christmas turkey and decided to give it a shot. The youtuber didn't just cook the entire turkey as a whole. Instead he cut it into different parts, and cooked them simultaneously at two different durations for optimal results. This was ingenious as dual probes can be extremely helpful for certain foods that require different doneness, and this thermometer monitors both the internal temperature of the food and the ambient temperature.
Fast forward two weeks in, and I'm in love with this thermometer. Even though I have an instant food thermometer, I still find myself using the Sync more because you can leave the probe in to get readings instead of having to manually stick the probes in like you would with a traditional food thermometer. As an experienced chef, even though most foods look cooked on the outside, you can never really judge their internal doneness without a thermometer.
1. Highly accurate: Each probe has 5 sensors for multi-zone temperature readings ensuring the lowest point of the internal temperature is displayed with accuracy down to the decimal. I cowitnessed the readings with a high-end instant-read thermometer, and all the readings were consistent with each other. It also comes with an external ambient temperature sensor which is important because, ambient temps may vary in different parts of the oven/smoker/grill. I cowitnessed the ambients temps as well and they were also consistent.
2. Easy to connect: It can easily connect to my phone via wifi or Bluetooth. Once set up, it's super easy to use every time.
3. Stable connection: The wifi or Bluetooth connection is very stable. I've used Sync in a smoker for several cooks now, and even when it was wrapped in foil with a the lid of the smoker on, it never lost connection. There were no complex syncing issues or signal losses.
4. You can monitor the cooking progress from anywhere in your home where you can take your phone or tablet. You don't have to stay in the kitchen.
5. You can set preferences for various alerts via the app.
6. The built-in cooking time estimator is great when you're in charge of larger meals or just want to know when to lower the heat. The app will tell you when the food is done and allow a rest period for the temperature to rise. For example, if you want a medium steak and set the temperature to 135℉, the app will tell you the steak is done when it reaches 130℉ and to allow a 3-5 minute rest period for the temperature to rise to 135℉. This means you can cook proteins perfectly every time.
7. It has a large base screen that's easy to read.
8. Charging is very convenient. Just plug in the charging cable to charge the base, and stick the probes into the base to charge the probes.
9. You can select a preset in the app modify it according to your preferences.
10. Customer service. Initially, when my Sync was not charging, I contacted customer service. To my surprise, they responded quickly and offered to replace the device for free if it was defective. I was very impressed with their quick response and friendly attitude.
11. The 3-year warranty is a nice bonus.
Hopefully this review has been helpful. I'll update this review if my views change or I find more ways to use it. If you're concerned about the price being higher than entry-level products, then you probably haven't taken the time to read this.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 15, 2024
★★★★★ 5
Efficient, accurate, and thoughtfully designed
This instant-read thermometer from Typhur does exactly what it promises, quick, accurate readings with no fuss. It’s fast, reliable, and has become one of those tools I reach for constantly in the kitchen.
The display is bright, clear, and easy to read. It even auto-rotates based on how you're holding it, so the numbers are always right side up, no more twisting your neck trying to read upside-down temps.
One of my favorite features is the magnetic back. Being able to attach it to the fridge keeps it visible and within arm’s reach when I need it most, no digging through drawers mid-cook. It’s a small detail, but one that adds a lot of everyday convenience.
Unlike some of Typhur’s other products that charge via USB-C, this one runs on batteries. At first I found that a little unusual, but on second thought, I actually appreciate it. No internal battery means no long-term degradation, just pop in fresh batteries when needed and keep it going. That kind of longevity makes sense for a kitchen tool like this.
Best part? I scored it on sale for under $40, which was a steal. Even at its current price point around $100, it still feels fair for the quality and performance you're getting.
Highly recommended if you’re looking for an instant-read thermometer that blends speed, accuracy, and solid design.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 4, 2025
★★★★★ 5
Precision meets style - a game changer for culinary enthusiasts
Just received Typhur InstaProbe my latest kitchen gadget, an ultra-premium meat thermometer, and let me tell you - this is not your average thermometer. It cost about a lot more than the standard meat thermometer, but every single penny is worth it for the level of accuracy and convenience it brings to the table.
The speed and precision of this thermometer are unrivaled. It takes readings in a split second, completely eliminating the need to wait around while your hand hovers over the heat, or loss of precious heat from your oven. The accuracy is pinpoint - to the decimal. No more guesswork, no more undercooked or overcooked meats. Every meal I've made since getting this thermometer has been cooked to absolute perfection, making me feel like a gourmet chef in my own kitchen.
The aesthetic and tactile quality of this thermometer is another feature that sets it apart. It's sleek, modern, and feels premium in your hand. It's not just a tool, but an accessory to my kitchen that is both functional and pleasing to the eye.
Despite the price tag, this thermometer is worth considering for those who value precision, speed, and style in their cooking. The level of control it gives you over your cooking is unparalleled, and it's incredibly easy to use. It's a must-have for serious home cooks, barbecue enthusiasts, or anyone who values precision in their cooking. It's a worthwhile investment that will transform your cooking experience and elevate your meals to new heights. And as the old saying goes - you get what you pay for. With this premium meat thermometer, you're getting the very best.
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Reviewed in the United States on June 12, 2023
★★★★★ 5
Great quality
I’m just a hobbyist, but this is the best fast read temperature probe I’ve ever used. Performance is top notch. The build quality is excellent, especially the display screen. You will be able to read it in any light situation. The temperature reading stabilized very quickly, ambidextrous response is also very fast. Obviously to turn the unit on you will need to swing the probe out. It has good magnet strength, but, in cases where you have a true stainless steel grill or prep table, just lay it down, in out position, it will awaken within a second when picked up. Close the probe, it will stay off till next use. The box it is shipped in makes for great storage, just make sure to keep the outer sleeve of the box. The probe itself is very sharp (but, be careful) unlike some others, which makes it very easy to push in to the most delicate, to the very tough cuts of meat at any temperature. It uses 2AAA batteries which are are very versatile, unlike the 2032 lithium batteries that others use. I understand that alot of people use these products in cold temperatures in which alkaline batteries will not work well, but you can get AAA lithium batteries for cold weather conditions. Just make sure you remove the alkaline batteries when the probe will not be used for long periods of time due to corrosion. All in all, a great product, it’s built with quality materials and should last a very long time. Quality over quantity. Also, they offer a 10 year warranty once you register your probe. They actually reached out to me after I purchased it and left a phone number. I called them and actually spoke to a real representative of the company. You may pay more for this temp probe than 100’s of others that are less expensive, but, I feel that Typhur stands behind their products.
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Reviewed in the United States on June 26, 2024
★★★★★ 5
Fast, Accurate, and Fancy - The Ultimate Thermometer Experience!
I recently purchased this thermometer, and I am beyond impressed with its performance, design, and user experience. The key features that set it apart are its speed, accuracy, and the inclusion of a fancy OLED display.
The very first thing I noticed was how fast this thermometer delivers accurate readings. Within mere seconds, I had a precise temperature reading, eliminating the need for any guesswork. I've tested it on multiple occasions, and it consistently provided reliable results.
One aspect that truly stands out is the fancy OLED display. Not only is it aesthetically pleasing, but it also enhances the user experience by providing clear and easy-to-read measurements. The display is bright and visible even in low light conditions, making it incredibly convenient for those late-night fever checks.
In summary, this thermometer is a fantastic investment for anyone in need of a fast, accurate, and visually appealing device. Its remarkable speed, precision, and the added touch of a fancy OLED display make it a must-have in any household.
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Reviewed in the United States on May 2, 2023
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