SKU: 6591556221

Natural Factors Acetyl-L-Carnitine 500mg - 60 Capsules

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Description

Natural Factors Acetyl-L-Carnitine 500mg - 60 CapsulesProduct Information Carnitine and its derivatives exist in a carnitine pool in the body. Cellular enzymes and transporters rapidly convert the carnitine to the required form and transport it to the tissues. Carnitine and its derivatives play a key role in fat, carbohydrate, and protein metabolism and energy production and are critical components for mitochondrial metabolism. Acetyl L carnitine (ALC) is the most important derivative of carnitine and

Product Information

Carnitine and its derivatives exist in a carnitine “pool” in the body. Cellular enzymes and transporters rapidly convert the carnitine to the required form and transport it to the tissues. Carnitine and its derivatives play a key role in fat, carbohydrate, and protein metabolism and energy production and are critical components for mitochondrial metabolism. Acetyl-L-carnitine (ALC) is the most important derivative of carnitine and occurs naturally in the body. Because ALC is considered to have greater bioavailability and is therefore more able to cross neurological membranes, it is the preferred form to take for promoting neurological health. 

The levels of carnitine and its derivatives are critical to normal biological functioning. Carnitine is present in the diet in red meats and dairy products, and humans can make carnitine from the amino acids lysine and methionine. However, carnitine deficiency can occur with metabolic disorders, and in conditions such as diabetic neuropathy (nerve pain) and other complications of diabetes. 

ALC has been studied in various conditions including neurological and cognitive disorders such as Alzheimer’s, dementia, depression, neuropathies, and cardiovascular disease, as well as with respect to the fatigue and pain associated with conditions such as chronic fatigue syndrome and sciatica.

Main selling features

  • The most important derivative of carnitine, and the preferred form to take, as it is the most bioavailable
  • Able to cross the blood-brain barrier
  • Has many neurological benefits, including cognitive ability, memory, and mood
  • Naturally occurring nutrient, free from toxic effects

How it works

Acetyl-L-carnitine is the most abundant naturally occurring derivative of carnitine. ALC helps the body produce energy at the cellular level; regulates carbohydrate, lipid and protein metabolism; facilitates fatty acid entry into the mitochondria; and maintains the homeostasis of coenzyme A. ALC also displays potent antioxidant effects and supports repair mechanisms. ALC has been shown to support heart and brain function, muscle movement, and numerous other body processes. 

ALC protects and enhances the activity of neurons and transmitters in the mitochondria and reduces oxidative stress. By improving cellular function and effi ciency in the mitochondria, ALC stabilizes the fl uidity and function of cell membranes, and improves energy production. ALC is involved in peripheral nerve regeneration and has shown promise in improving neuropathy. Because ALC is able to cross the blood-brain barrier it is able to exert its neuroprotective effects in the brain. Studies have shown ALC can improve cognitive performance and mood by protecting against oxidative stress and reducing or blocking the neuronal death that occurs with dementia and other neurodegenerative conditions. 

Supplementation with ALC may be useful in a broad range of conditions, including Alzheimer’s, dementia, age-related memory loss and depression, fatigue, diabetic neuropathy, and cardiovascular disease.

Positioning Line

Boosts physical and mental energy

Ingredients
Each Capsule Contains:  
Acetyl-L-Carnitine 
(N-Acetyl L-carnitine hydrochloride)
500 mg

Non-Medicinal ingredients

Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.  

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SKU: 6591556221

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4.1 ★★★★★
Based on 23 reviews
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Product Reviews
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Verified Purchase
Janice D. Hunter
Pawtucket, US
★★★★★ 5
Wonderful Bone Loved by Dogs
Flavor Name: Bacon, Size: Medium
Dogs love all the knobs. Easy for them to hold.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 17, 2026
D
Verified Purchase
Debbie
Charlottesville, US
★★★★★ 5
Cocker Spaniel loves it!
Flavor Name: Bacon, Size: Medium
(Check out Cocker Spaniel video) Every dog deserves a toy made with heart. From the irresistible bacon flavor to the durable nylon design, each chew toy is crafted with purpose—to give your dog joy, comfort, and a safe way to chew. Make sure to replace it after they’ve worn it out!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 20, 2025
N
Verified Purchase
Nunya B
Boise, US
★★★★★ 5
Sturdy
Flavor Name: Bacon, Size: Medium
My French Bulldogs have really strong jaws and are aggressive chewers. These really are sturdy and last a good amount of time. I replace every couple of months and they are one of my dogs favorites and easy for them to hold onto.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 25, 2026
A
Verified Purchase
Amazon Customer
Grantham, US
★★★★★ 5
Lasts forever
Flavor Name: Bacon, Size: X-Large
Gizmo, my 92lb Labrador puppy, just loves this toy. He’s had one since he was 3 months old, and he just had his birthday. Absolutely good for hours of contented chewing and tossing. Highly recommended!
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Reviewed in the United States on June 6, 2026
H
Verified Purchase
happyfeeshie
Cuba, US
★★★★★ 4
Our dogs love these bones.
Flavor Name: Bacon, Size: X-Large
ALWAYS SUPERVISE A DOG WHEN THEY ARE CHEWING OR EATING. It doesn't matter what it is, they can choke on anything, we have had multiple instances where we have had to intervene to prevent or stop choking. I also was going to give this a 5 star review, but after reading the other reviews I didn't. The pet product industry really needs to educate the consumer more about pets and what type would do best with their product. Either way, I think my experience might be helpful to some and we are pretty happy with these bones because the dogs are. Here's the short version of my recommendations: I do not recommend Nylabones for dogs that are teething If an adult dog is chewing non-stop, Kongs with treats or peanut butter are great to help break up the chewing time. Even if they won't chew the Kong, they'll definitely stop whatever they are doing and lick out all of the peanut butter, which is actually calming and tiring for dogs. It might be worth trying a much larger size bone if you have a smaller dog. I never had small dogs until now, but the large bone seems to tire our 20 pound dogs out quicker than the smaller bones ever did, and their little jaws seem to handle it just fine. All of our dogs are gnawing with their back teeth at an angle on the white nyla part, as though they are rubbing their teeth against it to clean and sharpen them. The other type of chewing would use more of the front teeth and pull, like they're cleaning meat off of a bone, which isn't the right kind of chewer for Nylabones. Ours only occasionally chew them like that, so I know they are eating some pieces but it doesn't seem to affect their health since it's pretty limited and small (like a crumb). Here's my experience with these bones: We got our first Nylabone's for small breed puppies about a 18 months ago (not this product but same brand), and the puppies did try swallowing big chunks, so this type of bone was not great for them yet. However, our old large breed dog decided he wanted to chew on the small puppy bones too, so I got him the large one of this bone because it's huge with four points, and more his size. It could be a challenge for dogs who don't use their paws like hands, but ours seem to figure it out comfortable ways to chew on it. The old dog absolutely loved it, and had no big chunk issues. He very quickly figured out not to chew the red part because it is a totally different plastic than the white part (which is whatever "Nyla" is). My understanding from the package is that the white part is somewhat digestible, or safely passes through in very small pieces. I specifically remember that being why I decided to try these. Our big dog used to choke on raw hides when he was younger, so we had to stop all chewing things (which just meant more treats and walks so he was happy!), but now that he is older he is really enjoying this bone. Our old dog did wear one down to the nubs after about 3-6 months, and continued chewing on it occasionally (less often since there is less there to chew, and I knew I was supposed to toss it but he loved it so much). So I just got him a new one, but he still carries around the old one to show it off when we come in the door. He's chewing the new one now, so he seems to understand that the old one is 'done', and I haven't felt the need to take it away for safety reasons. The funny part is that the small dogs (now 2 yr old) actually chew on his large bone too, it's pretty comical given the size difference. I got them the extra-small versions and they haven't shown much interest in those. I decided to also get one for our new 'store' dog who is about 1.5 yrs old and a lab/boxer mix and lives at the store full time. It was to help him transition away from his neurotic tail biting and rope bone that is falling apart from his prior home (where he was EXTREMELY bored and was getting into everything). He has enjoyed the Nylabone for about 2 weeks. I don't think it's worn down too much yet, but he's definitely going to wear his out faster (maybe 2+ months?) than our other three dogs combined, but his teeth are also sharper and he chews more, so that's fair. So far, no pieces or chunks from the Nylabone. He also hasn't had a problem leaving the red part alone and he's learning how to use his paws more because of the shape of this thing. He still uses it when he's bored, but we've started increasing his training practice, so hopefully he'll be past the chewing phase by 2 yr old, and he has stopped getting into anything (like trash or 'stuff left out' that dogs manage to get into). He's also a huge and a very active dog, so having regular customers and activity help tire him out more than any bone can. Best of luck!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 31, 2019

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