Pay in installments of $70.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 23 - Jul 28
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
MUC18/CD146 His Tag Protein, HumanProduct Specification Species Human Synonyms METCAM, CD146, Melanoma cell adhesion molecule, MCAM, Cell surface glycoprotein MUC18, Gicerin, MUC18, MelCAM, HEMCAM Accession P43121 Amino Acid Sequence Val24 Gly559, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | METCAM, CD146, Melanoma cell adhesion molecule, MCAM, Cell surface glycoprotein MUC18, Gicerin, MUC18, MelCAM, HEMCAM |
| Accession | P43121 |
| Amino Acid Sequence | Val24-Gly559, with C-terminal 10*His VPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 80-100kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Mills L. et al. (2002) Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 62(17): 5106-5114. 2、Taira E. et al. (2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J Cell Physiol. 198(3): 377-387. 3、Fritzsche F R. et al. (2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-464. |
Background
CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some studies have highlighted the significance of CD146 and its soluble form in angiogenesis and inflammation, having been shown to contribute to the pathogenesis of many inflammatory autoimmune diseases, such as systemic sclerosis, mellitus diabetes, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.3 ★★★★★
Based on 12 reviews
Sort
Product Reviews
★★★★★ 5
Dog loves snakey!
Style: Rainbow Snake
Is great for play loving dog..with gentle mouth.
Surprisingly, it has really held up after tons of tugging.
I didn’t think it would bc is not heavy duty material or stitching,
rather is soft & light weight. Has plenty of squeakers too!
- Darker colors would be nice! Human preference. :)
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 20, 2024
★★★★★ 3
Poor quality and materials
Style: Rainbow Snake
I bought this for my 8 week old German Shorthaired Pointer puppy. Within 24 hours the majority of the squeakers were dead, and about 1/3 of the squeakers had been removed. The material is not strong and easily ripped open. I gave 3 stars because my puppy liked the toy, but the quality was not good. I expect to be throwing this toy in the garbage by the end of the week.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 29, 2025
★★★★★ 4
Here for a good time, not a long time
Style: Rainbow Snake, Style: Rainbow Snake
Our puppy loved his snake. Within 10 minutes he already had one of the squeakers out! Not very good quality for the price in my opinion. 6 weeks later and every squeaker is out and all the stuffing! He still plays with it even though it is just a piece of cloth now. I gave it 4 stars because he still loves it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 15, 2026
★★★★★ 1
Quality has gone down from previous ones
Style: Rainbow Snake
I've bought two of these - my dog goes crazy for them! She's only 12 lbs and not a big chewer. The first one lasted a few years, before the squeakers gave out and the seams opened (I got that one at Marshall's). The second one I got more recently on Amazon. It fell apart in just a few weeks.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 11, 2025
★★★★★ 2
Don’t bother spending your money
Style: Rainbow Snake
This dog toy is definitely not worth the money. It is cheaply made and the squeakers are so close to surface that my dog will destroy it in no time. There is hardly any filling in the toy. I do not recommend!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 20, 2024
recommand products
Beige Color Net Fabric Festival Wear Embroidered work Glorious Salwar Suit
51.24
Sea Green Color Rayon Fabric Tempting Asmita Sood Salwar Suit
36.12
Pink Color Function Wear Embroidered Georgette Fabric Designer Salwar Suit
74.76
Sangeet Wear Georgette Fabric Purple Color Embroidered Palazzo Suit
71.40
Peach Color Party Wear Thread Embroidered Georgette Straight Cut Dress
64.68