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Description
HB-EGF Protein, MouseProduct Specification Species Mouse Synonyms Proheparin binding EGF like growth factor (HB EGF) Accession Q06186 Amino Acid Sequence Asp63 Leu148 Expression System E. coli Molecular Weight 14kDa (Reducing) Purity 95% by SDS PAGE and HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 300mM NaCl, pH8. 0, 1mM DTT Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Mouse |
| Synonyms | Proheparin-binding EGF-like growth factor (HB-EGF) |
| Accession | Q06186 |
| Amino Acid Sequence | Asp63-Leu148 |
| Expression System | E.coli |
| Molecular Weight | 14kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE and HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 300mM NaCl, pH8.0, 1mM DTT |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Cancer Metastasis Rev. 2018 Sep;37(2-3):385-395. |
Background
Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a 13-15kDa member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds to the EGF receptor with a higher affinity and has been shown to be more mitogenic, likely due to its ability to bind to heparin and heparin sulfate proteoglycans. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function. The transmembrane form of HB-EGF is the unique receptor for diptheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces, heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions.
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4.5 ★★★★★
Based on 1650 reviews
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Product Reviews
★★★★★ 5
Excellent Car Sound Deadening and Heat Insulation Solution
Material Type: 157mil Closed Cell Foam, Style: 157 mil 36 SqFt
If you're looking for a high-quality car sound deadening and heat insulation material, then the Siless Liner 157 (4 mm) mil 36 sqft is definitely worth considering. This product is designed to offer superior noise reduction and heat insulation for your car, making your driving experience more comfortable and enjoyable.
The closed-cell foam material used in this product is of premium quality, and it effectively blocks out external noise and vibrations. This means you can enjoy a quieter and more peaceful ride, even on noisy roads. In addition, the Siless Liner 157 also provides excellent heat insulation, which can help keep your car cooler in hot weather.
One of the best things about this product is that it's very easy to install. You don't need any special tools or equipment, and the material can be easily cut to fit any shape or size. It's also very lightweight and flexible, which makes it easy to work with.
Overall, the Siless Liner 157 (4 mm) mil 36 sqft Car Sound Deadening Closed Cell Foam & Heat Insulation mat is an excellent choice for anyone looking to improve the comfort and performance of their car. It's a high-quality product that delivers on its promises, and it's definitely worth the investment.
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Reviewed in the United States on March 12, 2023
★★★★★ 4
Heavy-Duty That Works!
Material Type: 157mil Closed Cell Foam, Style: 157 mil 36 SqFt
This extreme sound deadening mat performs well for reducing road noise and vibration. It feels dense and adheres securely when properly applied. Once installed, it noticeably improves interior quietness.
Overall, it’s a strong choice for more serious sound insulation projects.
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Reviewed in the United States on May 12, 2026
★★★★★ 5
Good product, quite sticky I must say.
Material Type: 157mil Closed Cell Foam, Style: 157 mil 36 SqFt
Worked for my van insulation
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Reviewed in the United States on June 1, 2026
★★★★★ 5
Good stuff
Material Type: 157mil Closed Cell Foam, Style: 157 mil 36 SqFt
Good stuff, easy to use, self adhesive backing contours around curves easily and works great.
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Reviewed in the United States on April 29, 2026
★★★★★ 5
Works amazingly, but only if you install it correctly.
Material Type: 157mil Closed Cell Foam, Style: 157 mil 36 SqFt
If you purchasing Siless Liner 157 mil (4 mm) Sound Deadening mat, to block unwanted sounds in your car, this is what you need to buy. But wait! It's not the only thing you need to buy if you want to "actually" deaden sound.
By itself, it will definitely block a noticeable amount of sound, and, most likely, that's all you realistically need. But... But... If you want the Siless Liner Sound Deadening Mat to really help you take it up a few notches, to get the best sound almost bordering on soundproofing, listen up.
You will have to install traditional butyl rubber first. Doesn't have to be the Siless brand, but I'm sure they would love to sell both to you, I used both Killmat (80mil) and Noico (50mil).
I have a Honda S2000. It's a two-seater convertible sports car if you don't know what this car is, and it's loud when I'm driving above 60mph. I also happen to have a sound system installed as well. Other than that, the car is stock. I first installed the butyl rubber on the car's interior sheet metal. I went all out and covered everything I could. I didn't need to but I wanted to. I was extremely impressed with the results. But I wanted to go further. Not because I needed to but because just wanted to see what it would be like.
So I bought Siless Liner 157 mil (4 mm) 36sqft Sound Deadening mat to go on top of the butyl rubber mats. I put this over every area I installed the butyl rubber. I had to be careful of clearance issues since I added a significant amount of underlayment, and you should too.
If you put butyl rubber sound-deadening materials in 50% of the total interior area, you'll hear a noticeable improvement. If you put butyl in about 80% of the total area, you'll be even more amazed at the improvement, compared to before.
I originally did all the above myself, so that's my experience and so your mileage may vary.
I then installed the Siless Liner Sound Deadening mat over every place I could even going further than I could with the butyl rubber. I used the Siles Liner in areas where butyl rubber would not have been effective, such as the roll bar hoop area and large empty cavities or holes.
I covered everything I could, firewall, doors, floor pan, transmission tunnel, trunk, trunk lid, fuel tank area, rear quarter panels, and rear-wheel tunnels, in Siless Liner Sound Deadening Mat.
WOW!! The Siless Liner Sound Deadening Mat was the icing on the cake! Let's not forget, this car is a convertible sports car so it will never be a quiet ride, ever. But I can now actually have a conversation with a passenger at a normal-ish volume! This also means I can now have a normal hands-free phone call without having to plug one ear to block out the noise! My sound system sounds so much better! Just by going through the install process, I looked for any vibration, rattle, squeak, and noise-prone areas to either eliminate or reduce unwanted noise production. If you forget this step, the inside and outside of your car will rattle and buzz. I skipped this step the first time around. But did it right before I installed more butyl rubber and the improvement was impressive, especially inside the car. Outside the car, I didn't notice a difference until I put the last layer of Siless Liner Sound Deadening Mat. The sound deadening mat works both ways from what I can tell. If I turned up my music, as loud as I occasionally do, parked in the attached garage to the house, with the garage door closed, I would be barely able to tell the car was playing music in the garage. It sounds like it is another car, just a little bit down the street, with a very loud base. If you stand 20 feet away outside the car, the sound system is noticeable, but not obnoxious by a long shot.
Get a 3 piece wood/metal roller set as well, which makes quick work of large areas.
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Reviewed in the United States on December 23, 2021