SKU: 45370106869

MYH7 Recombinant Rabbit mAb (SDT-2936-44)

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Description

MYH7 Recombinant Rabbit mAb (SDT-2936-44)Product Specification Host Rabbit Antigen MYH7 Synonyms Myosin 7; Myosin heavy chain 7; Myosin heavy chain slow isoform (MyHC slow); Myosin heavy chain; cardiac muscle beta isoform (MyHC beta); MYHCB Immunogen Synthetic Peptide Location Cytoplasm Accession P12883 Clone Number SDT 2936 44 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 25 mg ml Conjugation Unconjugated

Product Specification


Host Rabbit
Antigen MYH7
Synonyms Myosin-7; Myosin heavy chain 7; Myosin heavy chain slow isoform (MyHC-slow); Myosin heavy chain; cardiac muscle beta isoform (MyHC-beta); MYHCB
Immunogen Synthetic Peptide
Location Cytoplasm
Accession P12883
Clone Number SDT-2936-44
Antibody Type Recombinant mAb
Isotype IgG
Application IHC-P, IF
Reactivity Hu, Ms, Rt
Purification Protein A
Concentration 0.25 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
IHC-P 1:2000 Hu, Ms, Rt
IF 1:1000-1:2000 Hu, Ms, Rt

Background

MYH7, the slow/cardiac β-myosin heavy chain encoded by the MYH7 gene on chromosome 14q12, is the dominant motor protein of the human ventricle and type I skeletal muscle fibers, forming the hexameric thick-filament complex (two MYH7, two ELC, two RLC) whose ATP-driven conformational cycles generate ≈2 pN of force at 5–10 nm steps; pathogenic missense or truncating variants disrupt this chemomechanical cycle and the accompanying α-helical coiled-coil packing, producing a dosage-sensitive spectrum of disease—hypertrophic and dilated cardiomyopathy, myosin storage myopathy, Laing distal myopathy—characterized by hypertrophic sarcomeres, replacement fibrosis, and progressive heart or skeletal muscle failure, while physiologically MYH7 expression is induced by thyroid hormone, exercise, and β-adrenergic signaling that up-regulate slow oxidative programs, making the protein a central therapeutic target for small-molecule myosin inhibitors (mavacamten) and gene-editing strategies aimed at normalizing contractile kinetics and Ca²⁺ sensitivity.

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SKU: 45370106869

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4.5 ★★★★★
Based on 19 reviews
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C
Verified Purchase
Chris B
Whiting, US
★★★★★ 5
Unmatched Pillow with Unmatched Customer Service!!! 5 STAR ALL AROUND
Team Name: Eden Cool+, Size: King, Color: Classic
## A Dream Come True (and Customer Service to Match!) From the moment I first laid my head on the Coop Eden Cool+ pillow, I knew I'd found something special. It's truly a game-changer for hot sleepers like me. The "Cool+" technology isn't just a gimmick; it actually works to keep my head and neck comfortably cool throughout the night, leading to the most refreshing sleep I've had in years. The adjustable fill is brilliant, allowing me to customize the loft perfectly for my sleep style, which means no more waking up with neck pain. The support is fantastic – it cradles my head without feeling too firm, and it holds its shape beautifully. However, what truly elevates my experience to a full five stars, beyond the exceptional product itself, is the **dedicated and outstanding customer service**. I had a minor issue with my initial pillow (a rare manufacturing defect, which can happen with any product). I reached out to Coop Home Goods, and their response was nothing short of phenomenal. They were incredibly prompt, empathetic, and went above and beyond to resolve the issue swiftly and completely. They genuinely cared about my satisfaction and ensured I was left with a perfect product. It's rare to find a company that not only produces a superior product but also stands behind it with such integrity and genuine concern for their customers. The Coop Eden Cool+ pillow is an investment in your sleep, and knowing that you're backed by such an incredible customer service team makes it an even easier decision. Highly, highly recommend!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 8, 2025
R
Verified Purchase
River
Boise, US
★★★★★ 5
So comfy
Size: King (Pack of 1), Style: Standard Loft (4" - 5")
I spent time looking up/watching videos on pillows for neck pain and this one comes up a lot. I’m someone that used to wake up every few weeks with a stiff neck so bad it could make me cry at work. I haven’t had that happen once after months of using this pillow. I look forward to laying my head down on it every night. It’s a luxury experience every time. I think what it does so well is maintain its shape. You can really squish it up how you want and it stays there even after hours. Moldable but somehow still firm. It’s expensive but to me the value is there because I no longer get crazy neck pain from sleep. Worth trying it out for sure. Btw I was stuck between this is and Purple brands couple top end options. I never got around to trying them because I tried this one first and was very satisfied! Feb 2026. Still use it every night and it's still protecting me from neck pain I used to get from sleeping. It's held up amazing. Hope to use it for many more years.
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Reviewed in the United States on January 18, 2025
A
Verified Purchase
Amazon Customer
Belleville, US
★★★★★ 5
Saatva Pillow is great
Size: Standard/Queen (Pack of 1), Style: Standard Loft (4" - 5")
So far this is the best pillow I have had in the last 10 years and I have tried two Purple pillows a couple different memory foam and Gel pillows at least 4 more pillows that I can't even remember the names of. My neck and shoulders are almost pain free. I have also been doing more stretching of my arms which is also helping, but this pillow has really made the most difference in the pain I have had, I felt difference from the first time I put my head on it. It's comfortable, the perfect height I got the 4"-5", I also got the queen size and it's great. It supports my head just right. I also ordered the Saatva Classic 14" mattress from the company and I sure hope it's as good or better would be great because I have back issues for the last 50 years.
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Reviewed in the United States on September 16, 2025
Y
Verified Purchase
YL
Lowell, US
★★★★★ 1
Cotton Fluff Around a Mostly Empty Bag
Size: King (Pack of 1), Style: High Loft (6"-7")
Bought the high-loft king, thinking it would be a great (tall) side-sleeper. What I got? A very nice, completely compressible cotton outer shell wrapped around a bag a bit smaller than a standard pillow. In that bag? A tiny amount of small latex chunks, just about a third full. That’s right, some cotton fluff around a basically empty bag. Could you buy some latex yourself and add it? No, the bag is sewn shut. You could probably fill a small pillow with latex you bought elsewhere and put that in. But seriously, what did you pay Saatva for in that case? Probably as close as I’ve seen a major/high-reputation company get towards a literal example of rip off.
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Reviewed in the United States on May 31, 2026
P
Verified Purchase
Perry Baker
Lake Worth, US
★★★★★ 3
Wrong item ships/decent pillow/price unjustified
Size: Standard/Queen (Pack of 1), Style: Standard Loft (4" - 5")
Sent me the wrong pillow twice in a row. It said high loft and standard loft on the packing, not sure what the problem is. I ordered standard loft both times, and both times they sent high loft. That name is very deceiving though. If what I have is high loft, the standard loft wouldn’t be much thicker than your standard flat down pillow. If you’d like any sort of neck support I’d suggest starting with the high loft and going down instead of the other way around. I am 5’ 7” 130lbs and this pillow does not lift my neck up further than neutral, which is a good thing. Shredded memory foam pillows are significantly higher or thicker if that helps. Pillow itself grew on me. You can definitely feel that there is a different material in the center of the pillow. I ordered it as a gift and ended up keeping both pillows. The price tag on this item is absolutely outrageous. I would have never ordered it for myself. Saatva products don’t last in my experience, we got their firmest mattress and within 2 years it was sagging horribly. I am interested to see how long this pillow lasts!
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Reviewed in the United States on January 19, 2026

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