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Description
Phospho- Zap-70 (Tyr319)/Syk (Tyr352) Recombinant Rabbit mAb (S-1252-12)Product Specification Host Rabbit Antigen Phospho Zap 70 (Tyr319) Syk (Tyr352) Synonyms Tyrosine protein kinase ZAP 70; 70 kDa zeta chain associated protein; Syk related tyrosine kinase; SRK; ZAP70; Tyrosine protein kinase SYK; Spleen tyrosine kinase; p72 Syk; SYK Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Cell membrane, Synapse Accession P43403 P43405 Clone Number S 1252 12 Antibody Type Recombinant mAb Isotype IgG Application WB,
Product Specification
| Host | Rabbit |
| Antigen | Phospho- Zap-70 (Tyr319)/Syk (Tyr352) |
| Synonyms | Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase; SRK; ZAP70; Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk; SYK |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Cell membrane, Synapse |
| Accession | P43403、 P43405 |
| Clone Number | S-1252-12 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000-1:2000 | Hu, Rt |
| ICC | 1:500 | Hu |
Background
Phospho-Zap-70 (Tyr319)/Syk (Tyr352) is the dually phosphorylated, catalytically active form of the tandem SH2-bearing Syk family tyrosine kinases Zap-70 and Syk, wherein phosphorylation of Tyr319 in Zap-70 (or the homologous Tyr352 in Syk) within the interdomain B linker induces an open conformation that relieves autoinhibition, promotes recruitment to doubly phosphorylated ITAM motifs of the T-cell receptor (Zap-70) or B-cell receptor (Syk) signaling complexes, and creates docking sites for downstream adaptors such as LAT and BLNK, thereby propagating calcium flux, MAPK activation, and transcriptional programs essential for lymphocyte development, activation, and effector function.
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