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Description
PE Rat Anti-Human IL-21 Antibody (S-3523)Product Specification Host Rat Antigen IL 21 Synonyms Interleukin 21; Za11; IL21 Location Secreted Accession Q9HBE4 Clone Number S 3523 Antibody Type Rat mAb Isotype IgG1,k Application ICFCM Reactivity Hu Positive Sample Th1 polarized human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation PE Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8
Product Specification
| Host | Rat |
| Antigen | IL-21 |
| Synonyms | Interleukin-21; Za11; IL21 |
| Location | Secreted |
| Accession | Q9HBE4 |
| Clone Number | S-3523 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | Th1 polarized human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 5μl per million cells in 100μl volume | Hu |
Background
Interleukin-21 (IL-21) is a four-α-helical-bundle type I cytokine produced mainly by activated CD4⁺ T helper cells, NKT cells and TFH cells that signals through a heterodimeric receptor composed of the IL-21R and the common γ-chain (γc) to activate JAK1/JAK3–STAT1/STAT3 pathways, thereby orchestrating a broad immunomodulatory program that drives the differentiation, proliferation and effector function of B cells into long-lived plasma cells and memory B cells, promotes the development of Th17 and Tfh subsets while suppressing Treg stability, enhances cytotoxic activity and survival of CD8⁺ T cells and NK cells, and synergizes with IFN-γ or IL-15 to amplify antiviral and antitumor immunity, making it a key molecular hub whose dysregulation contributes to autoimmune pathologies such as systemic lupus erythematosus and type 1 diabetes and whose exogenous delivery or blockade is being therapeutically exploited in cancer immunotherapy, chronic viral infections and allergy.
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