SKU: 64897659155

Mouse Anti-Human TCR α/β Antibody (S-R686)

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Description

Mouse Anti-Human TCR α/β Antibody (S-R686)Product Specification Host Mouse Antigen TCR Synonyms TCR; TCR Location Cell membrane Accession P01848 P01850 Clone Number S R686 Antibody Type Mouse mAb Application FCM Reactivity Hu Positive Sample Human PBMC Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied. Dilution application dilution species FCM 1: 200 Hu

Product Specification


Host Mouse
Antigen TCR α/β
Synonyms α/β TCR; TCR α/β
Location Cell membrane
Accession P01848、 P01850
Clone Number S-R686
Antibody Type Mouse mAb
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 1:200 Hu

Background

The T cell receptor (TCR) α and β proteins are essential components of the αβ T cell receptor, a heterodimeric surface protein expressed on T lymphocytes that recognizes antigenic peptides presented by major histocompatibility complex (MHC) molecules. The TCR α chain is encoded by the TRAC (T cell receptor alpha constant) and TRAV (T cell receptor alpha variable) genes, while the TCR β chain is encoded by the TRBC (T cell receptor beta constant) and TRBV (T cell receptor beta variable) genes, along with diversity (TRBD) and joining (TRBJ) segments, enabling extensive combinatorial diversity. Structurally, both chains consist of a variable (V) domain responsible for antigen recognition and a constant (C) domain that anchors the receptor to the cell membrane. The TCR αβ heterodimer associates with the CD3 complex (CD3γε, CD3δε, and CD247 ζζ) to form a functional TCR-CD3 signaling unit, which transmits activation signals upon peptide-MHC engagement. TCR β undergoes V(D)J recombination during thymic development, contributing to the receptor's antigen specificity, whereas TCR α lacks a D segment but still undergoes recombination for diversity. Mutations or dysregulation in TCR α/β genes can lead to immune disorders, including T cell malignancies and autoimmune diseases. TCR αβ T cells are critical for adaptive immunity, mediating responses against infections, tumors, and self-antigens in autoimmune conditions.

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SKU: 64897659155

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4.6 ★★★★★
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J
Jonathan
Cuba, US
★★★★★ 2
Wrong sizes
Hey I ordered an XL for this suit the coat is correct but my pants and vest is a Large can you please resend another try before you buy so I can see if it all fits before my wedding soon 😅
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 3, 2024
J
J.m.green
Chelsea, US
★★★★★ 5
Really nice suit.
Great suit. Fits well. I had to have the button on the jacket moved but other than that it fits well. Can adjust the vest. Decent material, light wait but not cheap. All the stitching is nice. Was a good length and pants fit well.
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Reviewed in the United States on August 27, 2023
D
Verified Purchase
DMWms.
Phoenix, US
★★★★★ 5
Get Em!
Awesome fit especially the lil elastic band in the waist.
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Reviewed in the United States on March 17, 2025
Z
Z
Lake Worth, US
★★★★★ 5
really comfortable
these fit really well and look really nice on me. theyre stretchy and the material is high quality. i would definitely recommend these.
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Reviewed in the United States on February 2, 2025
K
Verified Purchase
krystal smith
Lowell, US
★★★★★ 5
Perfect suit
Color: Wine Red, Size: X-Large, Color: Wine Red, Size: X-Large
I love the suit it fitted my son perfect
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Reviewed in the United States on April 26, 2026

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