SKU: 74748852520

USP14 His Tag Protein, Human

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Description

USP14 His Tag Protein, HumanProduct Specification Species Human Synonyms Ubiquitin carboxyl terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin specific processing protease Accession P54578 Amino Acid Sequence Pro2 Gln494

Product Specification


Species Human
Synonyms Ubiquitin carboxyl-terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease
Accession P54578
Amino Acid Sequence

Pro2-Gln494 PLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQGGGSHHHHHHHH

Expression System Baculovirus-InsectCells
Molecular Weight 58kDa (Reducing)
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Liquid
Storage Buffer 20mM Hepes, 100mM NaCl, 10%Glycerol, 3mMDTT pH8.0
Stability & Storage

·12 months from date of receipt, -20 to -70 °C as supplied.
·1 month, 2 to 8 °C under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Reference

Front Pharmacol. 2022 Jan 5:12:801328. J Cell Physiol. 2021 May;236(5):3396-3405. Epub 2020 Nov 1.

Background

Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein degradation. USP14 protects protein substrates from degradation by removing ubiquitin chains from proteasome-bound substrates, whereas promotes protein degradation by activating the proteasome. Increasing evidence have shown that USP14 is involved in several canonical signaling pathways, correlating with cancer, neurodegenerative diseases, autophagy, immune responses, and viral infections. The activity of USP14 is tightly regulated to ensure its function in various cellular processes. Due to its intriguing roles in the stabilization of disease-causing proteins and oncology targets, USP14 has garnered widespread interest as a therapeutic target.

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SKU: 74748852520

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4.3 ★★★★★
Based on 5 reviews
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D
Verified Purchase
Different from what I expected
Lexington, US
★★★★★ 5
Cozy, warm and not heavy
Color: White, Size: Queen
This blanket is great and for a fair price, so fluffy and it’s on the warmer side but not heavy, which is exactly what I wanted!
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Reviewed in the United States on May 9, 2026
P
Verified Purchase
Pam
Fort Morgan, US
★★★★★ 5
Not Bulky, Not Too Warm
Color: White, Size: Twin
This is a great comforter. I have purchased others that were way too bulky. This one is perfect. It is lightweight and seems ideal for warmer temperatures. I am not too hot in the middle of the night. We are heading into Summer but I am sure this will be fine for Summer heat or for Air Conditioners.
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Reviewed in the United States on May 7, 2026
J
Verified Purchase
Jelly Captor
Boise, US
★★★★★ 5
Exceptional Comfort and Warmth!
I recently purchased the quilted covers for my king-size bed, and I couldn't be more pleased with the product. This blanket not only fits my wife and me comfortably, but it has also become our go-to choice for exceptionally cold winter nights. What surprised me the most is the incredible warmth provided by such a light blanket. It's one of the lightest blankets I've ever felt, yet it manages to keep us cozy and warm throughout the night. The quality of insulation is truly exceptional. Another highlight of this quilted cover is its ease of maintenance. It's incredibly easy to wash, maintaining its softness and fluffiness after each wash. The softness is akin to lying on a cloud, making it a delightful experience every time we use it. The overall design and craftsmanship of the blanket are top-notch. It's not only functional but also adds a touch of luxury to our bed. The fluffiness and cloud-like softness make it a perfect companion for a good night's sleep. In conclusion, I highly recommend the quilted covers for anyone looking for a combination of comfort, warmth, and ease of care. It has exceeded my expectations in every aspect, and I am more than satisfied with this exceptional product.
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Reviewed in the United States on January 24, 2024
V
Verified Purchase
Vero
Dallas, US
★★★★★ 5
Unexpensive and great for summer
Size: King, Color: White
Light, synthetic, but oeko tex label. White, breathable, easy to wash and dry, comfy, seems a great quality. It will last for a while.
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Reviewed in the United States on January 19, 2026
K
Verified Purchase
Kanlia Riley
Natrona Heights, US
★★★★★ 5
A 5 star WIN - such a soft, so fluffy, perfect cloud duvet comforter that feels expensive but isn't. Like sleeping in a cloud.
My fiance' and I both had king size duvets - mine from Ikea, down alternative, a few years old, and I'm not sure where his was from, but his was true goose down/feathers. After going away for the weekend to stay at a lovely vacation home, we got a bit spoiled with the comfortable bed and great linens there, so when we came home we decided it was time for a bed makeover. Since I love to research, I spent hours scouring Amazon for something that looked like it was actually a great comforter at a great price. This duvet is everything we wanted and more. Oh my GOSH...it is SO fluffy. SO soft. It's my marshmallow cloud comforter. The inside fill has a silky soft feeling to it when you press on it - it sort of slides in your hands when you touch it, like the fill has a light, silky feel to it Even when I sit on the end of the bed to do something, I can feel how comfortable it is to just even sit on. It makes our old duvets seem pathetic, like something you'd go camp with. This duvet is as nice as the bedding we had where we stayed in our vacation home. It feels like it has medium weight, but it's warm - quite warm for the weight. We keep it cool in our home at night so for us it's perfect. The material is so soft. We covered it immediately with a beautiful cover because we want to keep it in perfect condition. I also notice that even though both of our old duvets were king size, this one (also a king) just seems bigger. Our bed is a queen and the king size fits perfectly over it, it drapes over the sides just far enough. Also, my fiance' likes to roll up in his covers when he sleeps. He has plenty of room to do that without taking any of the duvet from my side. :) Verdict - it's amazing, I feel like a princess sleeping under this duvet. It's amazing for this price, amazing. All 3 of us give it 5 stars - me, fiance' and our cat who now won't get off of our bed. Someone mentioned that it doesn't have loops on the corners. That's true, it doesn't, but you can always sew those on if you want to. I found a kit for that on amazon too. But trust me, this comforter is worth sewing loops if you really want them. However, like others, we haven't found that the comforter moves or shifts in the duvet cover at all. It stays very well, better than any of my old comforters did, and I've had a few. Perhaps it's the loft that keeps it in place so well. I'll check back in after some time to let you know if if stays nice.
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Reviewed in the United States on March 28, 2016

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