SKU: 21295556203

Litchi chinensis, Litchi (graine)

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Description

Litchi chinensis, Litchi (graine)Litchi chinensis Sonn. Macrat des graines brut Le Litchi est un fruit tropical qui fait parti de la culture traditionnelle chinoise aussi bien gastronomique que mdicinale et les tudes moderne ont confirms les indications dont la MTC (mdecine traditionnelle Chinoise) utilisait les graines du Litchi. Environ une centaine dtudes quasiment toutes faites par des quipes chinoises explorent des pistes autour des cancers (apoptose), de la maladie dAlzheimer,

Litchi chinensis Sonn. 

Macérat des graines brut

Le Litchi est un fruit tropical qui fait parti de la culture traditionnelle chinoise aussi bien gastronomique que médicinale et les études moderne ont confirmés les indications dont la MTC (médecine traditionnelle Chinoise) utilisait les graines du Litchi. Environ une centaine d’études quasiment toutes faites par des équipes chinoises explorent des pistes autour des cancers (apoptose), de la maladie d’Alzheimer, du diabète,  comme neuro-protecteur, reno-protecteur et contre l’obésité.

Ethnobotanique : 

Utilisé traditionnellement en MTC (médecine traditionnelle Chinoise) pour ces vertus :

-Modulation de la glycémie et des lipides

-Antioxydation

-Antivirus

-Antitumoral

Composants des graines :

-quercétine, 

-procyanidine A2 et le (2R), (possible inhibition des cytokines neuro-inflammatoires, inhibition de l’apoptose et possible facteur de nécrose tumorale)

-naringénine-7-O-(3-O-αL-rhamnopyranosyl-β-D-glucopyranoside), 

-catéchine  (neuro-protecteur)

Propriétés des graines  (scientifiquement démontrés) :

-Anticancéreuses (1)

-Inhibition de l’apoptose (4,5,7,15,16)

-Antibactériennes (1)

-Antioxydantes (1)

-Antiglycantes (diabète, antihyperglycémiques, diabète sucré de type II (T2DM)) (1,6,9)

-Régulation des lipides (1,9)

-Neuroprotection, anti-neuro-inflammatoire(1,3,4,5,7,8,14)

-Effet anti-neurotoxique  (1)

-Effet réno-protecteur (1)

-Maladie d’Alzheimer (2,4,6,7,8,14)

-Obésité et modulation du microbiote intestinal (10)

-Activité inhibitrice de la lipase pancréatique  (11)

-Néoplasmes urologiques dont le cancer de la prostate (12,13)


1.Zhang Y, Jin D, An X, Duan L, Duan Y, Lian F. Lychee Seed as a Potential Hypoglycemic Agent, and Exploration of its Underlying Mechanisms. Front Pharmacol. 2021 Oct 8;12:737803. doi: 10.3389/fphar.2021.737803. PMID: 34690773; PMCID: PMC8531476.

2.Qiu WQ, Pan R, Tang Y, Zhou XG, Wu JM, Yu L, Law BY, Ai W, Yu CL, Qin DL, Wu AG. Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction. Biomed Pharmacother. 2020 Oct;130:110575. doi: 10.1016/j.biopha.2020.110575. Epub 2020 Aug 5. PMID: 32768883.

3.Xiong R, Zhou XG, Tang Y, Wu JM, Sun YS, Teng JF, Pan R, Law BY, Zhao Y, Qiu WQ, Wang XL, Liu S, Wang YL, Yu L, Yu CL, Mei QB, Qin DL, Wu AG. Lychee seed polyphenol protects the blood-brain barrier through inhibiting Aβ(25-35)-induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1-mediated autophagy in bEnd.3 cells and APP/PS1 mice. Phytother Res. 2021 Feb;35(2):954-973. doi: 10.1002/ptr.6849. Epub 2020 Sep 6. PMID: 32893437.

4.Zhao Y, Zeng Y, Wu A, Yu C, Tang Y, Wang X, Xiong R, Chen H, Wu J, Qin D. Lychee Seed Fraction Inhibits Aβ(1-42)-Induced Neuroinflammation in BV-2 Cells via NF-κB Signaling Pathway. Front Pharmacol. 2018 Apr 23;9:380. doi: 10.3389/fphar.2018.00380. PMID: 29740316; PMCID: PMC5925968.

5.Tang Y, Xiong R, Wu AG, Yu CL, Zhao Y, Qiu WQ, Wang XL, Teng JF, Liu J, Chen HX, Wu JM, Qin DL. Polyphenols Derived from Lychee Seed Suppress Aβ (1-42)-Induced Neuroinflammation. Int J Mol Sci. 2018 Jul 20;19(7):2109. doi: 10.3390/ijms19072109. PMID: 30036972; PMCID: PMC6073121.

6.Tang Y, Yu C, Wu J, Chen H, Zeng Y, Wang X, Yang L, Mei Q, Cao S, Qin D. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. Int J Mol Med. 2018 Jan;41(1):251-263. doi: 10.3892/ijmm.2017.3245. Epub 2017 Nov 9. PMID: 29138799; PMCID: PMC5746317.

7.Wang X, Wu J, Yu C, Tang Y, Liu J, Chen H, Jin B, Mei Q, Cao S, Qin D. Lychee Seed Saponins Improve Cognitive Function and Prevent Neuronal Injury via Inhibiting Neuronal Apoptosis in a Rat Model of Alzheimer's Disease. Nutrients. 2017 Feb 4;9(2):105. doi: 10.3390/nu9020105. PMID: 28165366; PMCID: PMC5331536.

8.Zhang X, Wang Y, Qin Q, Wang Y, Xu J, He X. Pronounced anti-neuroinflammatory jasmonates and terpenes isolated from lychee seeds. Fitoterapia. 2021 Jul;152:104924. doi: 10.1016/j.fitote.2021.104924. Epub 2021 May 11. PMID: 33984432.

9.Contreras-Castro AI, Oidor-Chan VH, Bustamante-Camilo P, Pelayo-Zaldívar C, Díaz de León-Sánchez F, Mendoza-Espinoza JA. Chemical Characterization and Evaluation of the Antihyperglycemic Effect of Lychee (Litchi chinensis Sonn.) cv. Brewster. J Med Food. 2022 Jan;25(1):61-69. doi: 10.1089/jmf.2021.0098. Epub 2021 Dec 7. PMID: 34874786.

10.Xiang JY, Chi YY, Han JX, Kong P, Liang Z, Wang D, Xiang H, Xie Q. Litchi chinensis seed prevents obesity and modulates the gut microbiota and mycobiota compositions in high-fat diet-induced obese zebrafish. Food Funct. 2022 Mar 7;13(5):2832-2845. doi: 10.1039/d1fo03991a. PMID: 35179169.

11.Mhatre SV, Bhagit AA, Yadav RP. Proteinaceous Pancreatic Lipase Inhibitor from the Seed of Litchi chinensis. Food Technol Biotechnol. 2019 Mar;57(1):113-118. doi: 10.17113/ftb.57.01.19.5909. PMID: 31316283; PMCID: PMC6600303.

12.Chang M, Zhu D, Chen Y, Zhang W, Liu X, Li XL, Cheng Z, Su Z, Zhang J, Lu Y, Guo H. Total Flavonoids of Litchi Seed Attenuate Prostate Cancer Progression Via Inhibiting AKT/mTOR and NF-kB Signaling Pathways. Front Pharmacol. 2021 Sep 23;12:758219. doi: 10.3389/fphar.2021.758219. PMID: 34630125; PMCID: PMC8495171.

13.Guo H, Luo H, Yuan H, Xia Y, Shu P, Huang X, Lu Y, Liu X, Keller ET, Sun D, Deng J, Zhang J. Author Correction: Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling. Sci Rep. 2021 Jul 20;11(1):15201. doi: 10.1038/s41598-021-94623-5. Erratum for: Sci Rep. 2017 Jan 30;7:41656. PMID: 34285337; PMCID: PMC8292357.

14.Sun Y, Wu A, Li X, Qin D, Jin B, Liu J, Tang Y, Wu J, Yu C. The seed of Litchi chinensis fraction ameliorates hippocampal neuronal injury in an Aβ25-35-induced Alzheimer's disease rat model via the AKT/GSK-3β pathway. Pharm Biol. 2020 Dec;58(1):35-43. doi: 10.1080/13880209.2019.1697298. PMID: 31881157; PMCID: PMC6968628.

15.Hsu CP, Lin CC, Huang CC, Lin YH, Chou JC, Tsia YT, Su JR, Chung YC. Induction of apoptosis and cell cycle arrest in human colorectal carcinoma by Litchi seed extract. J Biomed Biotechnol. 2012;2012:341479. doi: 10.1155/2012/341479. Epub 2012 Oct 3. PMID: 23093841; PMCID: PMC3470890.

16.Liao Y, Luo Z, Liu Y, Xue W, He S, Chen X, Ren H, Yang X, Zhu D, Su Z, Huang Q, Guo H. Total flavonoids of Litchi seed attenuate stem cell-like properties in breast cancer by regulating Notch3 signaling pathway. J Ethnopharmacol. 2023 Apr 6;305:116133. doi: 10.1016/j.jep.2023.116133. Epub 2023 Jan 2. PMID: 36603788.

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4.0 ★★★★★
Based on 9 reviews
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Product Reviews
A
Verified Purchase
Amazon Customer
Carnegie, US
★★★★★ 5
Great toy
Color: Black/Orange
This brand really makes durable toys. They outlast every other toy my dogs have. One dog loves to get the squeaker out of any toy, but he doesn’t rip this one apart. Obviously it won’t last forever, but no toy does! Some other brands of toys only make it a day or two, while these last months to years.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 10, 2026
C
Verified Purchase
C Harper
Houston, US
★★★★★ 5
Super durable!
Color: 2PK Green Leaping Phrog
Yellow lab approved bc they are fun to chew. Mom approved because they last forever!
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Reviewed in the United States on January 7, 2026
A
Verified Purchase
Arele
Birmingham, US
★★★★★ 5
Great toy for two big German Shepherds
Color: Brown
We only buy Tuffy dog toys now because we have one German Shepherd, and we often watch our daughter's GSD too, and the two dogs tear anything else apart in minutes. Tuffy toys are BY FAR superior to any other dog toy we have tried. That being said, some Tuffy toys seem to last longer than others with the two dogs, and this one has been pretty good! We've had it for a few weeks now, and it's just now starting to show some white (stuffing) where their teeth have pierced the top of the toy. That's pretty good, considering they play tug of war with it and can tear into toys pretty hard. If it were just our one dog, I think it would last a lot longer because it's the tug of war between the two of them that does them in faster. Even so, when they do manage to tear the fabric in vulnerable places, I just pull the stuffing out from that area, and they continue to play with it, sometimes for months! This one is better than some other Tuffy toys too because it has lots of areas where there is already more fabric and reinforced seams than stuffing, like all the legs on the side, the tail, and even the pincers. So far, they haven't been able to tear into those at all. Just a bit on the top of the head, and so far, no stuffing coming out yet. This one is a big win for us! When they finally do do it in, I will turn around and buy another Scorch the Scorpion right away!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 5, 2014
D
Verified Purchase
Deholle
Boise, US
★★★★★ 4
Tuffy Desert Phrog vs Lola
Color: Green Leaping Phrog, Color: Green Leaping Phrog
Just a little background about my dog. Lola is a 5 year old corgi-terrier mix with jaws of steal. Lesser stuffed toys have met death in under 5 minutes. Tennis balls last less than a day. Rope toys that do not have frayed ends might possibly last a week (frayed ends never stand a chance). The only toys that she has not managed to destroy are her Kong, a Kong bone, and a racquet ball. I figured I would document the life span of Phrog (Tuffy Scale: 9) before making my final judgement on it’s durability. Day 1 - Phrog Arrives! Lola was very excited about the arrival of Phrog and immediately went into destruction mode. Phrog did sustain a little damage before we were able to bribe her to drop Phrog and get her understand that he was more fun to play fetch with than to mutilate. The white you see in the picture is not stuffing, but the second layer of defense for the toy. The fact that my living room is not full of stuffing and I didn’t have to pry a squeaker out of my dog’s mouth, I’d say Phrog wins the Day 1 challenge. Day 9 - Phrog has sustained a little more damage, but not anything life threatening. His side wound is a little bit larger and one of his eyes is half ripped off. For safety reasons, I am going to finish removing the damaged eye and some loose thread from various places. Other than that, Phrog is still holding up and holds top toy spot. I have also found him very useful for dealing with anxiety; the squeaker can often distract her from her stressors and Phrog takes the abuse of her frustrations. Day 16 - Phrog is starting to show signs of mortal wounds. Lola has made it through the thicker layer around his arm and I can see the stuffing. It is only a matter of time before gets all the way through. Day 60 - Phrog still lives!!! I have done some surgery on Phrog to reinforce the fabric around his arms, but Franken-Phrog is still the favorite of all of the toys. She will even get brave enough to rescue Phrog from the evil vacuum when he is kidnapped and tortured. I am thinking about purchasing Phrog II for the inevitable day when Phrog goes off to the pet toyland in the sky, but for now, there is only one Phrog for Lola.
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Reviewed in the United States on July 6, 2018
M
Verified Purchase
michael parsley
Alexandria, US
★★★★★ 5
Super tough
Color: Red Warthog
My dogs love these toys!!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 10, 2026

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