SKU: 95519574780

Metformin - 500 mg, 30 tablets

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Description

Metformin - 500 mg, 30 tabletsMetformin: Prescribed For Longevity A trusted, highly effective medication for lowering blood sugar and promoting a healthy metabolism. A favorite among biohackers and longevity experts for optimizing health and slowing the effects of aging. 3 5 Key Ingredient Metformin: 500mg per tablet. How It Works Metformin targets multiple pathways involved in glucose metabolism, with its primary effects driven by three key mechanisms: 1,6 8 Decreasing glucose

Metformin: Prescribed For Longevity

  • A trusted, highly effective medication for lowering blood sugar and promoting a healthy metabolism.
  • A favorite among biohackers and longevity experts for optimizing health and slowing the effects of aging. 3-5

Key Ingredient

  • Metformin: 500mg per tablet.

How It Works

  • Metformin targets multiple pathways involved in glucose metabolism, with its primary effects driven by three key mechanisms:1,6-8
    • Decreasing glucose production in the liver
    • Enhancing your body’s ability to use insulin
    • Slowing glucose absorption in the intestines

Health Benefits

  • Combats Sugar Spikes: Minimizes post-meal blood sugar fluctuations, supporting stable glucose levels.1,8
  • Boosts GLP-1: Activates the "feel full" hormone, aiding in appetite regulation and healthy weight management.6
  • Enhances Cellular Energy: Targets the mitochondrial respiratory chain, optimizes mitochondrial function, and supports mitochondrial regeneration (mitophagy).9,10
  • Balances the Gut Microbiome: Promotes a healthy gut environment for improved digestion and systemic well-being.1
  • Protects Heart and Brain: Supports vascular health and helps safeguard vital organs from age-related decline.12-16

Anti-Aging Benefits

Beyond Blood Sugar
Metformin is increasingly recognized as one of the most promising off-label drugs in the field of aging and longevity science. While it’s long been valued for its role in blood sugar regulation, a growing body of research suggests it may also help delay the aging process and extend healthy lifespan in vivo. This new and expanding evidence positions Metformin not only as a trusted treatment for metabolic conditions, but as a powerful tool for supporting long-term health and vitality.1,3-5,8,10,11,17,18

Targeting Health Span
The TAME (Targeting Aging with Metformin) Trial is a landmark clinical study poised to reshape how we think about aging. With nearly 3,000 participants between the ages of 65 and 79, this six-year study is evaluating Metformin’s impact on key age-related factors—including heart health, cognitive function, and cellular vitality. If successful, TAME could make Metformin the first widely used drug to directly target the biology of aging— establishing it as a cornerstone therapy to slow decline and extend healthspan. And the best part? You don’t have to wait for the trial to finish! Metformin is already available by prescription, offering those eligible a forward-thinking option to support long-term health today.4

Key Longevity Pathways Influenced by Metformin

Recent studies have identified multiple cellular effects of Metformin that may help explain its beneficial impact on metabolism and age-related health.1,4,6,8-13,19-30

  • Insulin Regulation
  • IGF-1 Signaling
  • mTOR Inhibition
  • Mitochondrial Function
  • Oxidative Stress Reduction
  • AMPK Activation
  • DNA Damage Reduction
  • Inflammation Modulation
  • Autophagy Activation
  • Cellular Senescence
  • Epigenetic Alteration
  • Microbiome Balance

Why Choose ProHealth Longevity?

  • Same-day prescription approval
  • No insurance required
  • Compounded by a US-licensed pharmacy
  • Lab tested for quality and safety
  • Expedited (2-day) shipping
  • Delivered directly to your home
  • In stock, ready to ship  

Reach Your Health Goals in 4 Simple Steps

  1. Health Questionnaire: Fill out a quick, 5-minute online health history form. 
  2. Doctor Review: A licensed medical professional will review your form to confirm eligibility.
  3. Expedited Shipping: Prescriptions will be shipped from a US-licensed, FDA-regulated pharmacy.
  4. At-Home Support: Receive 24/7 access to our care team through phone, text, or email for personalized guidance every step of the way.

 Get Started >>

FAQS 

Who should take Metformin?

Though traditionally used to manage type 2 diabetes, Metformin is being studied for its potential benefits in healthy aging. People without diabetes—particularly those with insulin resistance, elevated fasting glucose, excess weight, or a family history of metabolic conditions—may want to explore Metformin’s role in longevity with their healthcare provider.

How do I take Metformin?

Metformin is taken orally once or twice daily, with or after meals, to help reduce stomach upset and improve absorption.

Are there any side effects?

Metformin has a well-established safety profile, with most side effects being mild. Common side effects include nausea, stomach discomfort, and diarrhea, which often improve over time. More serious side effects are rare but can include severe allergic reactions and lactic acidosis—a buildup of lactic acid in the blood. This risk is higher in people with kidney disease, so doctors typically avoid prescribing metformin in those cases.

Additionally, long-term use of Metformin can lead to lower vitamin B12 levels. If your vitamin B12 levels become too low, vitamin B12 supplements can help. Also, some studies indicate that individuals over 65 with low muscle mass may find it more challenging to build muscle while taking Metformin.

Are there any special dietary requirements while using Metformin? 

While there are no specific foods you must include or avoid when taking Metformin, adopting healthy dietary habits can enhance your results. Pairing Metformin with a balanced diet and regular exercise, as recommended by your healthcare provider, is key to achieving your goals. Excessive alcohol consumption increases the risk of lactic acidosis and should be avoided or limited while on metformin. 

Can Metformin help with weight loss?

Yes, metformin has been associated with modest weight loss. It works by reducing appetite, improving insulin sensitivity, and encouraging the body to burn fat more efficiently. However, it’s not a weight loss drug—and it’s most effective when combined with a healthy diet and regular exercise. Results can vary from person to person.

Is Metformin approved by FDA for longevity benefits?

No, the FDA has approved Metformin only for the treatment of Type 2 diabetes. However, like many medications, it is sometimes prescribed off-label for other uses based on a healthcare provider’s judgment. Although Metformin is not FDA-approved for longevity, the agency has authorized its investigation in aging through the TAME (Targeting Aging with Metformin) Trial—a landmark study exploring its potential to slow age-related decline and extend healthspan.

How long does it take to receive my medication?

Once your doctor’s approval is secured—typically within 4 hours on weekdays or 12 hours on weekends—your order will ship via two-day expedited delivery. 

References:

1. Cho K et al. Sci Rep. 2015;5:8145. 
2. Hendrick V et al. Ann Clin Psychiatry. 2017;29(2):120-124. 
3. Anisimov VN et al. Aging (Albany NY). 2011;3(2):148-157. 
4. Barzilai N et al. Cell Metab. 2016;23(6):1060-1065. 
5. Anisimov VN et al. Cell Cycle. 2008;7(17):2769-2773. 
6. Duca F et al. Nat Med. 2015;21(5):506-511. 
7. Foretz M et al. J Clin Invest. 2010;120(7):2355-2369. 
8. Zheng Z et al. Diabetes. 2012;61(1):217-228. 
9. Bridges HR et al. Biochem J. 2014;462(3):476-487. 
10. De Haes W et al. Proc Natl Acad Sci U S A. 2014;111(24):E2501-E2509. 
11. Cabreiro F et al. Cell. 2013;153(1):228-239.  
12. Li JZ and Li YR. Cardiology. 2023;148(4):374-384.  
13. Xie Z et al. Diabetes. 2011;60(6):1770-1778.  
14. Doran W et al. BMJ Open Diabetes Res Care. 2024;12(1):e003548. 
15. Ma TC et al. Neurosci Lett. 2007;411(2):98-103. 
16. Campbell JM et al. J Alzheimers Dis. 2018;65(4):1225-1236. 
17. Anisimov VN et al. Cell Cycle. 2010;9(1):188-197. 
18. Martin-Montalva A et al. Nat Commun. 2013;4:2192. 
19. Kickstein E et al. Proc Natl Acad Sci U S A. 2010;107(50):21830-21835.  
20. Nair V et al. J Biol Chem. 2014;289(40):27692-27701. 
21. Liu B et al. Cell Cycle. 2011;10(17):2959-2966.  
22. Pérez-Revuelta BI et al. Cell Death Dis. 2014;5(5):e1209. 
23. Algire C et al. Cancer Prev Res (Phila). 2012;5(4):536-543. 
24. Batandier C et al. J Bioenerg Biomembr. 2006;38(1):33-42. 
25. Lu J et al. Life Sci. 2015;127:59-65. 
26. Song YM et al. Autophagy. 2015;11(1):46-59. 
27. Saisho Y et al. Endocr Metab Immune Disord Drug Targets. 2015;15(3):196-205. 
28. Lien F et al. J Clin Invest. 2014;124(3):1037-1051. 
29. Moiseeva O et al. Aging Cell. 2013;12(3):489-498. 
30. Jadhav KS et al. Mech Ageing Dev. 2013;134(11-12):548-559.

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Chely
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★★★★★ 5
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Color: Flat Black
Really good, powerful and practical for travel
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Reviewed in the United States on May 24, 2026
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TLD
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★★★★★ 5
Works Great So Far
Color: Flat Black
I've only used this item for one week. But it is working great. I primarily bought it to use when mixing protein powder, and it has performed great. The only concern that I might share is that it is made fairly lightweight, and I wonder how long it will last. But can, up to this point, recommend it.
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Reviewed in the United States on June 4, 2026
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Jay n Debbie (Pillars-Of-Truth)
Charlottesville, US
★★★★★ 5
Strong, Durable, and SIMPLE Frother
Color: Gray
Excellent frother! It is ‘SIMPLE’, yet very efficient blending. I love that it included a set of long-lasting batteries. The motor on this frother is strong and works great. The item itself is of durable quality. I have had mine for about 9 months and use it daily for my coffee and other drinks throughout my week, and the battery is still running. I even give it a spin after washing the frother spinner/coil. This helps to dry it thoroughly, as the motor is strong enough to blow away any excess water - and still - the batteries are functioning well. The price is just right…very affordable compared to other brands. I’m very pleased with this purchase and absolutely love that it also came with a stand. I display it on my counter everyday. There are 3 solid and Simple colors to choose from, making this an easier shopping experience. Excellent choice for gifting!
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Reviewed in the United States on March 19, 2026
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Avista
Pawtucket, US
★★★★★ 5
Found the perfect chai frother on a budget!
Color: Glossy Black
Okay so I'll be honest, I spent way too long researching milk frothers before pulling the trigger on this one lol. As someone who grew up drinking chai every single day, having a good frother is kind of a big deal in my house. This little thing has been absolutely worth every penny. First off – it's SO easy to use. My 7 year old actually thinks it's the coolest thing ever and wants to help make my morning coffee now, which is honestly adorable. It just works, no fuss, no learning curve. What really sold me compared to other options was the USB-C charging. No more buying AA batteries every few weeks – that stuff adds up! I just plug it into the same charger as my phone. Super convenient. And here's a small thing that matters more than you'd think – it stands on its own! I don't need a separate stand cluttering up my already busy kitchen counter. Build quality feels solid, the stainless steel whisk looks clean and is easy to rinse off. For the price, honestly I expected less. Highly recommend if you're on the fence!
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Reviewed in the United States on April 24, 2026
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Amazon Customer
Battle Creek, US
★★★★★ 5
Nice handheld frother!
Color: Glossy Black
Handheld frother....tiny but mighty! Holds a charge for a number of uses before needing to plug in. Easy to use, easy to clean and works well. Doesn't take up a bunch of real estate on the counter or in the drawer. I would totally recommend this product.
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Reviewed in the United States on May 31, 2026

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