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Ozempic Simon Law is 100 units of semaglutide a lot Semaglutide Weight Loss Dosing Guide for the First Loading Phase We now have two FDA approved drugs for MASLD MASH: Resmetirom (oral, THR agonist) Semaglutide (weekly SC, GLP 1 RA) side by side comparison, courtesy of @rabataller #MASLD #MASH #FattyLiver @_ILTS_ @EASLedu @AASLDtweets @novonordisk Scientific Poster: Resmetirom and Semaglutide in MASH Mouse Model Study Taconic Biosciences Managing GLP 1 Side Effects: Strategies for Success PlexusDx This week brought disappointing news from two major Alzheimer's trials on potential treatments that failed to slow progression of the disease: Novo Nordisk's semaglutide and Johnson & Johnson's Niranjan Bose
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4.5 ★★★★★
Based on 13 reviews
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Product Reviews
★★★★★ 5
It Works!
Size: Full-size Truck, SUV
When I bought my vehicle it didn't come with a spare. I knew what I was in for. I was on my way to an important meeting and as fate would have, the tire pressure indicator reported a flat. I imagined the worst but experienced the best!
The directions said to let all the air out of tire and remove the valve stem core, it seemed like I was making a bad situation worse. Then it said to attach the tube to the stem and squeeze the contents into the tire. I thought "this is never going to work" the fluid seemed too watery to seal anything, but I followed instructions, I reinstalled the valve core and reinflated the tire, and it worked!
I expected it to leak immediately, it didn't. It lasted all day and most of the next day until I could get the tire to the shop. They removed a nail and patched the hole, overall I'm very satisfied, I bought a replacement right away, just in case!
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Reviewed in the United States on May 20, 2026
★★★★★ 5
Better than the green goo
Size: Full-size Truck, SUV (2-pack)
Recently, while I was at work, I noticed that I had at some point run over a nail with my car. Normally, you'd take your car to the tire shop and let them plug the hole for you. Well, the only problem was that the nail decided that it was going to poke my tire where the sidewall meets the tread, and most shops will refuse to plug a tire when it's punctured there. Makes sense, it's a liability issue for them, so I can't blame them. That still leaves me with the problem of having a tire with a nail in it. So, I could either replace the tire with either a new or used tire, which is expensive or I can try using a sealant to try and get as many miles out of my tire as I can.
In the past, I had tried using the green goo sealant on nail holes, and while it works to get you 15 miles down the road, that's about it. Now, while TireJect doesn't recommend using their product on punctures on the shoulder of the tire, I decided that I'd give it a try to see if it would work. And as of writing this review, it's been about 10 days since I put TireJect in my tire, and so far, it hasn't leaked any air, despite it not being meant for the shoulder. When money isn't so tight, I'll probably go ahead and replace the tire, especially since there's only about 4/32 tread depth left, but for the time being, I'll keep running it, and hopefully it keeps holding pressure properly like it has been.
Now, as for how easy it is to use, the only tools you will need that aren't provided, is an air compressor to allow you to re-inflate the tire. The kit comes with everything else you will need, including a valve core removal tool and a syringe to add the sealant to your tire. To use this product, you will first need to carefully remove the valve core with the provided tool, careful not to lose the core, since it doesn't come with a replacement core. After that, thread the hose on the syringe on to your valve stem, and then carefully add the required amount of sealant to the syringe. If you accidentally spill some, wipe it off before it dries, so that it doesn't stain anything. From there, just push the goo into the tire with the plunger, adding more to the syringe as necessary. When you're all done, re-install the valve core into the valve stem snuggly, careful not to over-tighten, and air up the tire to the recommended PSI with your compressor. After all that is done, go take a short, slow drive to distribute the sealant, and then recheck your air pressure.
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Reviewed in the United States on July 29, 2025
★★★★★ 1
TPMS Compatability is a LIE
Size: Sedan, Crossover, Small Truck
2018 Subaru Impreza, with one tire with a slow leak (about 2 PSI a week) that I couldn't trace.
I bought the "Full-Size Sedan, Small Truck, Crossover" kit (the 6 oz. pouch) based on my tire size, 225/40/18.
After I removed the valve core, attached the dispensing hose and opened the cap, the product would not flow into the tire. I squeezed the pouch, but that only made the product leak out around the valve stem onto the wheel and driveway. I tried rotating the tire so the valve stem was at the top, and and also at the bottom. I even took the wheel off so I could get a fully vertical flow. Nothing worked. I finally gave up after only about half the product was dispensed, and I do think most of it went somewhere other than in the tire.
I reinstalled the valve core, remounted the wheel, plugged in my little lighter socket-powered compresseor, and tried to inflate the tire. And ... NOTHING. The pressure reading on the compressor immediately shot up to over 100 PSI, and it automatically shut off. Tried multiple times, with the same result. I again removed the valve core, and a) no air came out of the tire when I removed it, and b) even with no valve core the compressor still would not pump air into the tire. Clearly the gunk had completely blocked the valve/TPMS.
Fortunately, when I took the tire to Costco (where I'd bought it), they were able to fix the damage I'd done, as well as patching a small nail hole in the tread I hadn't seen (that was clearly the source of the slow leak) for no charge. Since I've already submitted a refund request, ultimately all it really cost me was my time and effort ... and a whole lot of stress.
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Reviewed in the United States on November 26, 2024
★★★★★ 5
Forget the gooey stuff, this product WORKS! See UPDATES 1 and 2
Size: Compact Car, Mid-size Sedan
I've had a slow leak in one of my tires for some time. It's a common thing with chrome plated alloy wheels, they get corrosion on the bead area where the tire seals and then you get a slow leak. This was the only product which is water soluble so it's not going to make a permanent mess inside the tire; additionally, it contains tiny bits of Tufsyn which is the material some tires are made from. So it's not just a liquid that is sealing the leak, it's tiny bits of rubber. I was putting 5 or 6 lbs of air in my tire every few days, and I could see that the tire was getting low. I installed this TireJect per the instructions a week ago and the tire appears to be doing great, despite the fact that we've had some very cold weather. (I didn't want to check it with a gauge while it was this cold out because just in case the tire's valve didn't seal all the way; I'll check with a gauge when this cold snap is past.) While I can't say for 100% sure that there is no more leak, I suspect that the leak has been sealed up completely. This is a product unlike the others and I think it's worth the price.
FIRST UPDATE: It has been two months and I haven't had to add any air at all to the tire where I used this product. There was a slow rim leak which was losing about a pound or so per day and it has been totally fixed. The car has sat for several days a few times, including in single digit cold weather, as well as driven regularly otherwise, and the tire hasn't lost any air. I think it's the micro Tufsyn fibers in this product which seal leaks better than some goopy glue stuff other brands are made of. I totally recommend this product!
SECOND UPDATE - it's been eleven months since I added this to my tire with the slow rim leak and I have not had to add air a single time. Not once. THIS STUFF WORKS. Forget the slime and foam and get this.
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Reviewed in the United States on December 5, 2024
★★★★★ 5
TireJECT cannot work miracles
Size: Compact Car, Mid-size Sedan, Size: Compact Car, Mid-size Sedan
TireJECT is a surprisingly thin fluid that supposedly contains fibers that must help stop up holes. Frankly I'm still confused as to how this stuff can plug a leak, but apparently it does. Tons of reviews say so.
I say apparently because the product did not completely stop a slow leak in my tire, but that's OK. I knew it likely wouldn't. I'll have to replace the tire unfortunately.
I had a garage install four nearly-new tires on my car. After installing, a heavy leak was discovered in one of them. They took the tire off again and found a small tear near the rim/bead of the sidewall. Since the tear would be flat against the rim, they suggested to let them try and repair it with tire patch adhesive and lots of bead sealer. They were confident, so I went for it. It seemed to work, but it went flat a few days later.
TireJECT seemed like the perfect solution to the slow leak since I wouldn't have to disturb the repair. I bought the kind without the syringe and regretted it immediately upon trying to use it. First, the valve stem removal tool broke as it loosened it. I had to buy a new tool down the road. When I went to inject, I squeezed as hard as I could but it just wouldn't flow past the TPM. It also kept leaking out of the flex joint of the nozzle. I had a huge syringe on hand, so I sucked up the rest from the bag, ziptied the hose on both ends and got the rest of the product into the tire. HURRAY!
The tire pressure had fallen considerably by the next morning. BOOOoo. I contacted TireJECT, and after several emails (and long waits in between). They determined their product was not suitable for my use case. They refunded what I paid without me even asking. I really appreciated that.
That said, before injecting, the tire would go flat overnight. So, TireJECT does work to a good degree. I'm half tempted to overdose the tire with another package.
Give TireJECT a try! Though, be sure your situation matches their criteria. If you have a TPM, opt for the package that comes with a syringe. You will need it. Also, throw the cast pot metal, tire stem tool out and get a decent machined one before you do the repair. Thank me later.
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Reviewed in the United States on April 1, 2025
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