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You might know them as Ozempic, Wegovy, Mounjaro,and Zepbound. GLP 1 receptor agonists are best known for managing diabetes and promoting weight loss, but researchers are discovering a wide spectrum of effective applications My thoughts exclusively > PPIs aren't working for many patients on GLP 1 therapies! Joshua Leito, PharmD, MHS Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with Glp 1 Receptor Agonists: A Multidisciplinary Expert Consensus Oral GLP 1: A Needle Free Solution for Weight Loss You've probably heard about the new weight loss injections. Ozempic. Wegovy. Mounjaro. They belong to a class of medications called GLP 1 drugs. But what does that actually mean? GLP 1 stands for glucagon like peptide 1. Schematic illustration of monoagonists, dual agonists and triple Download Scientific Diagram
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4.8 ★★★★★
Based on 1278 reviews
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Product Reviews
★★★★★ 4
Seems to have done a great job.
Size: Full-size Truck, SUV (2-pack)
One of our cars has suffered from rim leaks and was driving me nuts. Constantly being asked by my wife to top off the tires on her car. When I replaced a damaged rim I asked the tire shop to look for the source of the leaks. They said the "alloy" rims had started to corrode and did their best to get them to seal but warned me they would likely leak again. This spring when I removed her snow tires I found 3 of her 4 tires had gone completely flat in storage. The fourth was the new rim which was fine. I considered buying new rims that won't have this problem but wanted to wait until her times need to be replaced. The batteries in the TPMS sensors are getting very low so likely these will need to be replaced as well. I thought to try some sort of sealant. Most of the products I saw were not rated for automotive systems and offered warnings about risk to the TMPS sensors. This seemed to be the only product rated for my application and claimed it would not harm our car's sensors. So I gave it a shot. I ordered the SUV package that came with an injector and two 8-oz bottles. I put 4 oz in each tire per the instructions. Overall the process was easy except the valve core extractor broken on one of the tires. I had to pick up a replacement at a local auto parts store. Also, injecting the sealant creates a small amount of pressure in the tire that, if one doesn't release by drawing out the plunger, will burp a small amount of sealant onto the rims. Fairly easy to clean up with WARM water and easier to avoid after the first experience. Drove the car around at a variety of speeds for 10-15 minutes (had errands to run) and waited to see what happened. Great results. Weeks later and the tires still have the correct pressure. I am not sure how long this will last but hopefully for the remaining life of the tires at least. I took one star off for easy of use / easy to install because the valve core extractor is made of extremely cheap aluminum and I am sure others will have a poor experience with it. Be forewarned and consider buying one before you start jacking up your car and letting the air out of the tires only to find you break the tool on a sticky valve core and are unable to complete the job without a trip to the auto parts store. I'll update this review in about a year to report on the long-term outlook for this product.
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Reviewed in the United States on June 20, 2023
★★★★★ 5
It Works!
Size: Full-size Truck, SUV
When I bought my vehicle it didn't come with a spare. I knew what I was in for. I was on my way to an important meeting and as fate would have, the tire pressure indicator reported a flat. I imagined the worst but experienced the best!
The directions said to let all the air out of tire and remove the valve stem core, it seemed like I was making a bad situation worse. Then it said to attach the tube to the stem and squeeze the contents into the tire. I thought "this is never going to work" the fluid seemed too watery to seal anything, but I followed instructions, I reinstalled the valve core and reinflated the tire, and it worked!
I expected it to leak immediately, it didn't. It lasted all day and most of the next day until I could get the tire to the shop. They removed a nail and patched the hole, overall I'm very satisfied, I bought a replacement right away, just in case!
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Reviewed in the United States on May 20, 2026
★★★★★ 5
Better than the green goo
Size: Full-size Truck, SUV (2-pack)
Recently, while I was at work, I noticed that I had at some point run over a nail with my car. Normally, you'd take your car to the tire shop and let them plug the hole for you. Well, the only problem was that the nail decided that it was going to poke my tire where the sidewall meets the tread, and most shops will refuse to plug a tire when it's punctured there. Makes sense, it's a liability issue for them, so I can't blame them. That still leaves me with the problem of having a tire with a nail in it. So, I could either replace the tire with either a new or used tire, which is expensive or I can try using a sealant to try and get as many miles out of my tire as I can.
In the past, I had tried using the green goo sealant on nail holes, and while it works to get you 15 miles down the road, that's about it. Now, while TireJect doesn't recommend using their product on punctures on the shoulder of the tire, I decided that I'd give it a try to see if it would work. And as of writing this review, it's been about 10 days since I put TireJect in my tire, and so far, it hasn't leaked any air, despite it not being meant for the shoulder. When money isn't so tight, I'll probably go ahead and replace the tire, especially since there's only about 4/32 tread depth left, but for the time being, I'll keep running it, and hopefully it keeps holding pressure properly like it has been.
Now, as for how easy it is to use, the only tools you will need that aren't provided, is an air compressor to allow you to re-inflate the tire. The kit comes with everything else you will need, including a valve core removal tool and a syringe to add the sealant to your tire. To use this product, you will first need to carefully remove the valve core with the provided tool, careful not to lose the core, since it doesn't come with a replacement core. After that, thread the hose on the syringe on to your valve stem, and then carefully add the required amount of sealant to the syringe. If you accidentally spill some, wipe it off before it dries, so that it doesn't stain anything. From there, just push the goo into the tire with the plunger, adding more to the syringe as necessary. When you're all done, re-install the valve core into the valve stem snuggly, careful not to over-tighten, and air up the tire to the recommended PSI with your compressor. After all that is done, go take a short, slow drive to distribute the sealant, and then recheck your air pressure.
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Reviewed in the United States on July 29, 2025
★★★★★ 1
TPMS Compatability is a LIE
Size: Sedan, Crossover, Small Truck
2018 Subaru Impreza, with one tire with a slow leak (about 2 PSI a week) that I couldn't trace.
I bought the "Full-Size Sedan, Small Truck, Crossover" kit (the 6 oz. pouch) based on my tire size, 225/40/18.
After I removed the valve core, attached the dispensing hose and opened the cap, the product would not flow into the tire. I squeezed the pouch, but that only made the product leak out around the valve stem onto the wheel and driveway. I tried rotating the tire so the valve stem was at the top, and and also at the bottom. I even took the wheel off so I could get a fully vertical flow. Nothing worked. I finally gave up after only about half the product was dispensed, and I do think most of it went somewhere other than in the tire.
I reinstalled the valve core, remounted the wheel, plugged in my little lighter socket-powered compresseor, and tried to inflate the tire. And ... NOTHING. The pressure reading on the compressor immediately shot up to over 100 PSI, and it automatically shut off. Tried multiple times, with the same result. I again removed the valve core, and a) no air came out of the tire when I removed it, and b) even with no valve core the compressor still would not pump air into the tire. Clearly the gunk had completely blocked the valve/TPMS.
Fortunately, when I took the tire to Costco (where I'd bought it), they were able to fix the damage I'd done, as well as patching a small nail hole in the tread I hadn't seen (that was clearly the source of the slow leak) for no charge. Since I've already submitted a refund request, ultimately all it really cost me was my time and effort ... and a whole lot of stress.
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Reviewed in the United States on November 26, 2024
★★★★★ 5
Forget the gooey stuff, this product WORKS! See UPDATES 1 and 2
Size: Compact Car, Mid-size Sedan
I've had a slow leak in one of my tires for some time. It's a common thing with chrome plated alloy wheels, they get corrosion on the bead area where the tire seals and then you get a slow leak. This was the only product which is water soluble so it's not going to make a permanent mess inside the tire; additionally, it contains tiny bits of Tufsyn which is the material some tires are made from. So it's not just a liquid that is sealing the leak, it's tiny bits of rubber. I was putting 5 or 6 lbs of air in my tire every few days, and I could see that the tire was getting low. I installed this TireJect per the instructions a week ago and the tire appears to be doing great, despite the fact that we've had some very cold weather. (I didn't want to check it with a gauge while it was this cold out because just in case the tire's valve didn't seal all the way; I'll check with a gauge when this cold snap is past.) While I can't say for 100% sure that there is no more leak, I suspect that the leak has been sealed up completely. This is a product unlike the others and I think it's worth the price.
FIRST UPDATE: It has been two months and I haven't had to add any air at all to the tire where I used this product. There was a slow rim leak which was losing about a pound or so per day and it has been totally fixed. The car has sat for several days a few times, including in single digit cold weather, as well as driven regularly otherwise, and the tire hasn't lost any air. I think it's the micro Tufsyn fibers in this product which seal leaks better than some goopy glue stuff other brands are made of. I totally recommend this product!
SECOND UPDATE - it's been eleven months since I added this to my tire with the slow rim leak and I have not had to add air a single time. Not once. THIS STUFF WORKS. Forget the slime and foam and get this.
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Reviewed in the United States on December 5, 2024