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Description
Invivo anti-Mouse CD71 (TfR1) Recombinant mAbProduct Specification Host Rat Antigen CD71 (TfR1) Synonyms Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; Tfrc Location Cell membrane Accession Q62351 Clone Number S 3830 Antibody Type Rat mAb Isotype Rat IgG2a,k Application FCM Reactivity Ms Positive Sample Fresh C57BL 6 mouse bone marrow Purification Protein G Concentration 5 mg ml Purity >95%(Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rat |
| Antigen | CD71 (TfR1) |
| Synonyms | Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; Tfrc |
| Location | Cell membrane |
| Accession | Q62351 |
| Clone Number | S-3830 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | Fresh C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| FCM | 1:500 | Ms |
Background
CD71, also known as the transferrin receptor 1 (TfR1), is a type II transmembrane glycoprotein that plays a crucial role in cellular iron uptake by binding to transferrin, which facilitates iron transport into the cell. This receptor is highly expressed on rapidly proliferating cells, including erythroid precursors, activated immune cells, and cancer cells, as these cells require significant iron for DNA synthesis and metabolic processes. In clinical contexts, CD71 is used as a marker for identifying immature red blood cells (such as proerythroblasts and reticulocytes) and is also associated with aggressive tumor growth in various cancers, including pancreatic and colon cancers. Additionally, studies have shown that CD71 expression on neutrophils can be linked to poor prognosis in pancreatic ductal adenocarcinoma (PDAC) patients, indicating its potential as a prognostic biomarker.
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